Orlistat is a lipase inhibitor, reduces the absorption of dietary fat.
How to administer:
By mouth
120 mg up to 3 times a day, dose to be taken immediately before, during, or up to 1 hour after each main meal, continue treatment beyond 12 weeks only if weight loss since start of treatment exceeds 5% (target for initial weight loss may be lower in patients with type 2 diabetes), if a meal is missed or contains no fat, the dose of orlistat should be omitted
How to administer:
By mouth
120 mg up to 3 times a day, dose to be taken immediately before, during, or up to 1 hour after each main meal, continue treatment beyond 12 weeks only if weight loss since start of treatment exceeds 5% (target for initial weight loss may be lower in patients with type 2 diabetes), if a meal is missed or contains no fat, the dose of orlistat should be omitted
Contra-indication
Cholestasis; chronic malabsorption syndrome
Cautions
Chronic kidney disease; may impair absorption of fat-soluble vitamins; volume depletion
Cautions, further information
Vitamin supplementation (especially of vitamin D) may be considered if there is concern about deficiency of fat-soluble vitamins.